Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inNG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats
نویسندگان
چکیده
منابع مشابه
Improvement of Kidney Apelin and Apelin Receptor in Nitro-L-Arginine-Methyl Ester Induced Rats
1. Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Tarbiat Modarres, Tehran, Iran 2. Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran 3. Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran,...
متن کاملHypertensive response to chronic NG-nitro-L-arginine methyl ester (L-NAME) treatment is similar in immature and adult Wistar rats.
The aim of our study was to evaluate whether the blood pressure (BP) response to chronic inhibition of NO synthase (NOS) is exaggerated in young rats, which were reported to develop a more pronounced salt hypertension than the adult ones. The enhanced BP rise in immature rats subjected to excess salt intake might be due either to a generally increased reactivity in immature organisms to these s...
متن کاملEffect of aliskiren, telmisartan and torsemide on cardiac dysfunction in l-nitro arginine methyl ester (l-NAME) induced hypertension in rats
Comparative study of cardio protective effect of aliskiren, telmisartan, and torsemide was carried out on l-nitro arginine methyl ester (l-NAME) induced hypertension in rats. The three drugs were given daily for 8 weeks simultaneously with l-NAME, with a control group for each drug and l-NAME. The degree of protection was assessed by measurement of systolic blood pressure and heart rate of anim...
متن کاملMechanisms of the antihypertensive effects of Nigella sativa oil in L-NAME-induced hypertensive rats
OBJECTIVES This study was conducted to determine whether the blood pressure-lowering effect of Nigella sativa might be mediated by its effects on nitric oxide, angiotensin-converting enzyme, heme oxygenase and oxidative stress markers. METHODS Twenty-four adult male Sprague-Dawley rats were divided equally into 4 groups. One group served as the control (group 1), whereas the other three group...
متن کاملRenal effects of glucose transporter 4 in Nω-nitro-L-arginine/ /high salt-induced hypertensive rats.
OBJECTIVES The aim of study was to determine the renal effects of glucose transporter 4 (GLUT4) in a hypertensive nephropathy rat model. BACKGROUND GLUT4 has been implicated in insulin resistance and hypertension in several animal models; however its role in hypertensive nephropathy still remains unclear. METHODS Hypertensive nephropathy was induced by Nω-nitro-L-arginine (L-NNA), a nitric ...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2012
ISSN: 1388-0209,1744-5116
DOI: 10.3109/13880209.2012.684064